This document is a Defense Intelligence Reference Document (DIRD), a technical reference format used by the Defense Intelligence Agency (DIA) to capture baseline knowledge on a specific topic for later analytic use. DIRDs are best understood as reference and synthesis products rather than as original research. It is one of 38 DIRDs produced under the Advanced Aerospace Weapon System Applications Program (AAWSAP) between 2009 and 2011. Because AAWSAP’s scope permitted a broad range of supporting topics, not every DIRD in the series directly concerns aerospace systems or future threat assessment. The following summary reflects the DIRD’s scope and framing at the time of writing and should not be read as implying current validation of the concepts discussed. This DIRD surveys the structural materials needed for advanced aerospace platforms and argues that material choice cannot be separated from overall vehicle design, because launch vehicles, space vehicles, reusable systems, and propulsion hardware each face different temperature, durability, weight, and manufacturing constraints. The report reviews a range of candidate material classes, including advanced aluminum alloys; polymer-, aluminum-, and titanium-matrix composites; titanium alloys; nickel-base alloys; refractory metals; ceramic-matrix composites; carbon-carbon composites; and titanium aluminides. It emphasizes that balancing performance against practical limits such as fabrication methods, cost, inspection, contamination control, and service environment remains a major challenge. Its overall conclusion is that many promising materials exist, but their usefulness depends on application-specific tradeoffs and on closer integration of material selection with design and manufacturing, with some systems judged to be more valuable targets for development than others.